Show simple item record

dc.contributor.authorSühs, Kurt-Wolfram
dc.contributor.authorNovoselova, Natalia
dc.contributor.authorKuhn, Maike
dc.contributor.authorSeegers, Lena
dc.contributor.authorKaever, Volkhard
dc.contributor.authorMüller-Vahl, Kirsten
dc.contributor.authorTrebst, Corinna
dc.contributor.authorSkripuletz, Thomas
dc.contributor.authorStangel, Martin
dc.contributor.authorPessler, Frank
dc.identifier.citationJ Infect Dis. 2019 Feb 5. pii: 5307059. doi: 10.1093/infdis/jiz048.en_US
dc.description.abstractThe tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS infections would improve our understanding of pathophysiology and end-organ damage, and, furthermore, open doors to its evaluation as a source of diagnostic and/or prognostic biomarkers. We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 220 cerebrospinal fluid samples from patients with bacterial and viral (herpes simplex, varicella zoster, enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (anti-NMDA-R encephalitis, multiple sclerosis), and noninflamed controls (Bell's palsy, normal pressure hydrocephalus, Tourette syndrome). Kyn concentrations correlated strongly with CSF markers of neuroinflammation (leukocyte count, lactate, and blood-CSF-barrier dysfunction) and were highly increased in bacterial and viral CNS infections, but were low or undetectable in anti-NMDA-R encephalitis, multiple sclerosis, and controls. Trp was decreased mostly in viral CNS infections and neuroborreliosis. Multiple logistic regression analysis revealed combinations of Kyn, Trp and Kyn/Trp ratio with leukocyte count or lactate as accurate classifiers for the clinically important differentiation between neuroborreliosis, viral CNS infections, and autoimmune neuroinflammation. The Trp-Kyn-NAD+ pathway is activated in CNS infections and provides highly accurate CSF biomarkers, particularly when combined with standard CSF indices of neuroinflammation.en_US
dc.publisherOxford University Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.titleKynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.en_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7,30625 Hannover, Germany.en_US
dc.identifier.journalJournal of infectious diseasesen_US
dc.source.journaltitleThe Journal of infectious diseases

Files in this item

Sühs et al_final.pdf
original manuscript

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International