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dc.contributor.authorHalbedel, Sven
dc.contributor.authorPrager, Rita
dc.contributor.authorBanerji, Sangeeta
dc.contributor.authorKleta, Sylvia
dc.contributor.authorTrost, Eva
dc.contributor.authorNishanth, Gopala
dc.contributor.authorAlles, Georg
dc.contributor.authorHölzel, Christina
dc.contributor.authorSchlesiger, Friederike
dc.contributor.authorPietzka, Ariane
dc.contributor.authorSchlüter, Dirk
dc.contributor.authorFlieger, Antje
dc.date.accessioned2019-03-28T14:40:10Z
dc.date.available2019-03-28T14:40:10Z
dc.date.issued2019-01-01
dc.identifier.issn2222-1751
dc.identifier.pmid30866756
dc.identifier.doi10.1080/22221751.2018.1558960
dc.identifier.urihttp://hdl.handle.net/10033/621733
dc.description.abstractAn outbreak with a remarkable Listeria monocytogenes clone causing 163 cases of non-invasive listeriosis occurred in Germany in 2015. Core genome multi locus sequence typing grouped non-invasive outbreak isolates and isolates obtained from related food samples into a single cluster, but clearly separated genetically close isolates obtained from invasive listeriosis cases. A comparative genomic approach identified a premature stop codon in the chiB gene, encoding one of the two L. monocytogenes chitinases, which clustered with disease outcome. Correction of this premature stop codon in one representative gastroenteritis outbreak isolate restored chitinase production, but effects in infection experiments were not found. While the exact role of chitinases in virulence of L. monocytogenes is still not fully understood, our results now clearly show that ChiB-derived activity is not required to establish L. monocytogenes gastroenteritis in humans. This limits a possible role of ChiB in human listeriosis to later steps of the infection.en_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectMolecular surveillanceen_US
dc.subjectchitinen_US
dc.subjectcore genome MLSTen_US
dc.subjectinvasionen_US
dc.subjectlisteriosisen_US
dc.titleA Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany.en_US
dc.identifier.journalEmerging microbes & infectionsen_US
refterms.dateFOA2019-03-28T14:40:11Z
dc.source.journaltitleEmerging microbes & infections


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