The Effect of Cytochalasans on the Actin Cytoskeleton of Eukaryotic Cells and Preliminary Structure⁻Activity Relationships.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Luangsa-Ard, J Jennifer
Helaly, Soleiman E
Noumeur, Sara R
Stradal, Theresia E B
MetadataShow full item record
AbstractIn our ongoing search for new bioactive fungal metabolites, two new cytochalasans were isolated from stromata of the hypoxylaceous ascomycete Hypoxylon fragiforme. Their structures were elucidated via high-resolution mass spectrometry (HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. Together with 23 additional cytochalasans isolated from ascomata and mycelial cultures of different Ascomycota, they were tested on their ability to disrupt the actin cytoskeleton of mammal cells in a preliminary structure⁻activity relationship study. Out of all structural features, the presence of hydroxyl group at the C7 and C18 residues, as well as their stereochemistry, were determined as important factors affecting the potential to disrupt the actin cytoskeleton. Moreover, reversibility of the actin disrupting effects was tested, revealing no direct correlations between potency and reversibility in the tested compound group. Since the diverse bioactivity of cytochalasans is interesting for various applications in eukaryotes, the exact effect on eukaryotic cells will need to be determined, e.g., by follow-up studies involving medicinal chemistry and by inclusion of additional natural cytochalasans. The results are also discussed in relation to previous studies in the literature, including a recent report on the anti-Biofilm activities of essentially the same panel of compounds against the pathogenic bacterium, Staphylococcus aureus.
AffiliationHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Cytochalasans Act as Inhibitors of Biofilm Formation of Staphylococcus Aureus.
- Authors: Yuyama KT, Wendt L, Surup F, Kretz R, Chepkirui C, Wittstein K, Boonlarppradab C, Wongkanoun S, Luangsa-Ard J, Stadler M, Abraham WR
- Issue date: 2018 Oct 30
- Cytochalasans produced by Xylaria karyophthora and their biological activities.
- Authors: Lambert C, Shao L, Zeng H, Surup F, Saetang P, Aime MC, Husbands DR, Rottner K, Stradal TEB, Stadler M
- Issue date: 2023 May-Jun
- Cytochalasans and Their Impact on Actin Filament Remodeling.
- Authors: Lambert C, Schmidt K, Karger M, Stadler M, Stradal TEB, Rottner K
- Issue date: 2023 Aug 15
- Changes in secondary metabolism during stromatal ontogeny of Hypoxylon fragiforme.
- Authors: Stadler M, Quang DN, Tomita A, Hashimoto T, Asakawa Y
- Issue date: 2006 Jul
- Stereochemical determination of new cytochalasans from the plant endophytic fungus Trichoderma gamsii.
- Authors: Chen L, Liu YT, Song B, Zhang HW, Ding G, Liu XZ, Gu YC, Zou ZM
- Issue date: 2014 Jul