Salmonella persisters undermine host immune defenses during antibiotic treatment.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsStapels, Daphne A C
Hill, Peter W S
Westermann, Alexander J
Fisher, Robert A
Thurston, Teresa L
MetadataShow full item record
AbstractMany bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of Salmonella species by macrophages, nongrowing persisters also occur, but their physiological state is poorly understood. In this work, we show that Salmonella persisters arising during macrophage infection maintain a metabolically active state. Persisters reprogram macrophages by means of effectors secreted by the Salmonella pathogenicity island 2 type 3 secretion system. These effectors dampened proinflammatory innate immune responses and induced anti-inflammatory macrophage polarization. Such reprogramming allowed nongrowing Salmonella cells to survive for extended periods in their host. Persisters undermining host immune defenses might confer an advantage to the pathogen during relapse once antibiotic pressure is relieved.
CitationScience. 2018 Dec 7;362(6419):1156-1160. doi: 10.1126/science.aat7148.
AffiliationHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Internalization of Salmonella by macrophages induces formation of nonreplicating persisters.
- Authors: Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW
- Issue date: 2014 Jan 10
- [Advances in Salmonella pathogenicity island 2 type III secretion system - A review].
- Authors: Yin J, Li Q, Jiao X
- Issue date: 2016 Apr 4
- Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors.
- Authors: Sun H, Kamanova J, Lara-Tejero M, Galán JE
- Issue date: 2018 Oct
- Swiss Army Pathogen: The <i>Salmonella</i> Entry Toolkit.
- Authors: Hume PJ, Singh V, Davidson AC, Koronakis V
- Issue date: 2017
- A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.
- Authors: Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK, Brown ED
- Issue date: 2019 Jan 14