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Issue Date
2018-10-01
Metadata
Show full item recordAbstract
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA-protein interactions. Work over the years has identified major RBPs that act on cellular transcripts at the various stages of bacterial gene expression and that enable their integration into post-transcriptional networks that also comprise small non-coding RNAs. Bacterial RBP research has now entered a new era in which RNA sequencing-based methods permit mapping of RBP activity in a truly global manner in vivo. Moreover, the soaring interest in understudied members of host-associated microbiota and environmental communities is likely to unveil new RBPs and to greatly expand our knowledge of RNA-protein interactions in bacteria.Citation
Nat Rev Microbiol. 2018 Oct;16(10):601-615. doi: 10.1038/s41579-018-0049-5.Affiliation
HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.Publisher
Springer NatureJournal
Nature Reviews MicrobiologyPubMed ID
29995832Type
ArticleISSN
1740-1534ae974a485f413a2113503eed53cd6c53
10.1038/s41579-018-0049-5
Scopus Count
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