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dc.contributor.authorMurgia, Xabier
dc.contributor.authorLoretz, Brigitta
dc.contributor.authorHartwig, Olga
dc.contributor.authorHittinger, Marius
dc.contributor.authorLehr, Claus-Michael
dc.date.accessioned2019-05-08T08:02:13Z
dc.date.available2019-05-08T08:02:13Z
dc.date.issued2018-01-15
dc.identifier.citationAdv Drug Deliv Rev. 2018 Jan 15;124:82-97. doi: 10.1016/j.addr.2017.10.009. Epub 2017 Oct 26.en_US
dc.identifier.issn1872-8294
dc.identifier.pmid29106910
dc.identifier.doi10.1016/j.addr.2017.10.009
dc.identifier.urihttp://hdl.handle.net/10033/621764
dc.description.abstractA layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell debris. This complex composition yields a tenacious viscoelastic hydrogel that lubricates and protects the exposed epithelia from external threats and enzymatic degradation. The natural protective role of mucus is nowadays acknowledged as a major barrier to be overcome in non-invasive drug delivery. The heterogeneity of mucus components offers a wide range of potential chemical interaction sites for macromolecules, while the mesh-like architecture given to mucus by the intermolecular cross-linking of mucin molecules results in a dense network that physically, and in a size-dependent manner, hinders the diffusion of nanoparticles through mucus. Consequently, drug diffusion, epithelial absorption, drug bioavailability, and ultimately therapeutic outcomes of mucosal drug delivery can be attenuateden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHydrogelen_US
dc.subjectMucinsen_US
dc.subjectMucoadhesionen_US
dc.subjectMucopenetrationen_US
dc.subjectMucosal drug deliveryen_US
dc.subjectNanoparticlesen_US
dc.subjectPEGylationen_US
dc.subjectRheologyen_US
dc.titleThe role of mucus on drug transport and its potential to affect therapeutic outcomes.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAdvanced Drug Delivery Reviewsen_US
refterms.dateFOA2019-05-08T08:02:14Z
dc.source.journaltitleAdvanced drug delivery reviews


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International