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dc.contributor.authorWaldt, Natalie
dc.contributor.authorSeifert, Anke
dc.contributor.authorDemiray, Yunus Emre
dc.contributor.authorDevroe, Eric
dc.contributor.authorTurk, Benjamin E
dc.contributor.authorReichardt, Peter
dc.contributor.authorMix, Charlie
dc.contributor.authorReinhold, Annegret
dc.contributor.authorFreund, Christian
dc.contributor.authorMüller, Andreas J
dc.contributor.authorSchraven, Burkhart
dc.contributor.authorStork, Oliver
dc.contributor.authorKliche, Stefanie
dc.date.accessioned2019-05-13T14:16:36Z
dc.date.available2019-05-13T14:16:36Z
dc.date.issued2018-01-01
dc.identifier.citationFront Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018.en_US
dc.identifier.issn1664-3224
dc.identifier.pmid30568657
dc.identifier.doi10.3389/fimmu.2018.02852
dc.identifier.urihttp://hdl.handle.net/10033/621772
dc.description.abstractThe integrin LFA-1 (CD11a/CD18) plays a critical role in the interaction of T cells with antigen presenting cells (APCs) to promote lymphocyte differentiation and proliferation. This integrin can be present either in a closed or in an open active conformation and its activation upon T-cell receptor (TCR) stimulation is a critical step to allow interaction with APCs. In this study we demonstrate that the serine/threonine kinase Ndr2 is critically involved in the initiation of TCR-mediated LFA-1 activation (open conformation) in T cells. Ndr2 itself becomes activated upon TCR stimulation and phosphorylates the intracellular integrin binding partner Filamin A (FLNa) at serine 2152. This phosphorylation promotes the dissociation of FLNa from LFA-1, allowing for a subsequent association of Talin and Kindlin-3 which both stabilize the open conformation of LFA-1. Our data suggest that Ndr2 activation is a crucial step to initiate TCR-mediated LFA-1 activation in T cells.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectFilamin Aen_US
dc.subjectKindlin-3en_US
dc.subjectLFA-1en_US
dc.subjectNdr2en_US
dc.subjectT cellsen_US
dc.subjectTCRen_US
dc.subjectTalinen_US
dc.subjectinside-out signalingen_US
dc.titleFilamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig Germany.en_US
dc.identifier.journalFrontiers in immunologyen_US
refterms.dateFOA2019-05-13T14:16:36Z
dc.source.journaltitleFrontiers in immunology


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