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dc.contributor.authorWawro, Nina
dc.contributor.authorAmann, Ute
dc.contributor.authorButt, Julia
dc.contributor.authorMeisinger, Christa
dc.contributor.authorAkmatov, Manas K
dc.contributor.authorPessler, Frank
dc.contributor.authorPeters, Annette
dc.contributor.authorRathmann, Wolfgang
dc.contributor.authorKääb, Stefan
dc.contributor.authorWaterboer, Tim
dc.contributor.authorLinseisen, Jakob
dc.date.accessioned2019-05-20T11:36:36Z
dc.date.available2019-05-20T11:36:36Z
dc.date.issued2019-01-01
dc.identifier.citationFront Public Health. 2019 Apr 24;7:96. doi: 10.3389/fpubh.2019.00096. eCollection 2019.en_US
dc.identifier.issn2296-2565
dc.identifier.pmid31069210
dc.identifier.doi10.3389/fpubh.2019.00096
dc.identifier.urihttp://hdl.handle.net/10033/621784
dc.description.abstractIntroduction:Helicobacter pylori (H. pylori) is a common infection and known risk factor for gastric cancer. We assessed cross-sectional and longitudinal associations to study the impact of H. pylori seropositivity on metabolic diseases. Methods:Helicobacter pylori seropositivity in serum samples of the KORA study was analyzed by multiplex serology. We calculated sex-specific prevalence of H. pylori seropositivity for the year 2007 based on the first follow-up survey (termed F4) of the KORA study S4. We identified factors associated with H. pylori seropositivity in the F4 survey. Further, we assessed relative risks of incident metabolic diseases/risk factors at the time of the second follow-up survey of S4 (termed FF4) and H. pylori seropositivity at the F4 survey as a determinant. Models were adjusted for age, sex, overweight status, physical activity, smoking status, education level, alcohol intake, and other metabolic diseases. Results: Based on 3,037 persons aged 32 to 82 years, the H. pylori prevalence for 2007 was 30.2% in men (n = 1,465) and 28.1% in women (n = 1,572). Increasing age, current smoking, low education and no alcohol intake were significantly associated with H. pylori seropositivity in the F4 survey. However, no association between H. pylori seropositivity and BMI, metabolic diseases (type 2 diabetes, hypertension and dyslipidemia, gout or increased uric acid) and gastrointestinal diseases (gastritis, inflammatory bowel disease, and gastric or duodenal ulcer) was observed. No significant associations between H. pylori seropositivity and one of the five investigated incident metabolic diseases/risk factors were detected in the longitudinal analysis. Conclusion: We identified associations between age, smoking, education and alcohol intake and H. pylori seropositivity but no impact of H. pylori seropositivity on incident metabolic diseases/risk factors.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHelicobacter pylorien_US
dc.subjectinfectionen_US
dc.subjectmetabolic diseasesen_US
dc.subjectmultiplex serologyen_US
dc.subjectprevalenceen_US
dc.titleHelicobacter pylori seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in Public Healthen_US
refterms.dateFOA2019-05-20T11:36:36Z
dc.source.journaltitleFrontiers in public health


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