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dc.contributor.authorVieyres, Gabrielle
dc.contributor.authorPietschmann, Thomas
dc.date.accessioned2019-05-21T09:35:35Z
dc.date.available2019-05-21T09:35:35Z
dc.date.issued2019-03-12
dc.identifier.citationCells. 2019 Mar 12;8(3). pii: cells8030233. doi: 10.3390/cells8030233.en_US
dc.identifier.issn2073-4409
dc.identifier.pmid30871009
dc.identifier.doi10.3390/cells8030233
dc.identifier.urihttp://hdl.handle.net/10033/621788
dc.description.abstractThe replication cycle of the liver-tropic hepatitis C virus (HCV) is tightly connected to the host lipid metabolism, during the virus entry, replication, assembly and egress stages, but also while the virus circulates in the bloodstream. This interplay coins viral particle properties, governs viral cell tropism, and facilitates immune evasion. This review summarizes our knowledge of these interactions focusing on the late steps of the virus replication cycle. It builds on our understanding of the cell biology of lipid droplets and the biosynthesis of liver lipoproteins and attempts to explain how HCV hijacks these organelles and pathways to assemble its lipo-viro-particles. In particular, this review describes (i) the mechanisms of viral protein translocation to and from the lipid droplet surface and the orchestration of an interface between replication and assembly complexes, (ii) the importance of the triglyceride mobilization from the lipid droplets for HCV assembly, (iii) the interplay between HCV and the lipoprotein synthesis pathway including the role played by apolipoproteins in virion assembly, and finally (iv) the consequences of these complex virus–host interactions on the virion composition and its biophysical properties. The wealth of data accumulated in the past years on the role of the lipid metabolism in HCV assembly and its imprint on the virion properties will guide vaccine design efforts and reinforce our understanding of the hepatic lipid metabolism in health and disease.en_US
dc.language.isoenen_US
dc.publisherMPDIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectDGATen_US
dc.subjectVLDLen_US
dc.subjectapolipoproteinen_US
dc.subjecthepatitis C virusen_US
dc.subjectlipid dropleten_US
dc.subjectlipolysisen_US
dc.subjectlipoproteinen_US
dc.subjectmembrane contact sitesen_US
dc.subjectmolecular mimicryen_US
dc.subjectvirus assembly and releaseen_US
dc.titleHCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für Experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalCellsen_US
dc.source.journaltitleCells


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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International