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dc.contributor.authorJose, Bethany R
dc.contributor.authorGardner, Paul P
dc.contributor.authorBarquist, Lars
dc.date.accessioned2019-06-04T12:51:12Z
dc.date.available2019-06-04T12:51:12Z
dc.date.issued2019-04-30
dc.identifier.citationBiochem Soc Trans. 2019 Apr 30;47(2):527-539. doi: 10.1042/BST20180171. Epub 2019 Mar 5.en_US
dc.identifier.issn1470-8752
dc.identifier.pmid30837318
dc.identifier.doi10.1042/BST20180171
dc.identifier.urihttp://hdl.handle.net/10033/621797
dc.description.abstractUnderstanding how new genes originate and integrate into cellular networks is key to understanding evolution. Bacteria present unique opportunities for both the natural history and experimental study of gene origins, due to their large effective population sizes, rapid generation times, and ease of genetic manipulation. Bacterial small non-coding RNAs (sRNAs), in particular, many of which operate through a simple antisense regulatory logic, may serve as tractable models for exploring processes of gene origin and adaptation. Understanding how and on what timescales these regulatory molecules arise has important implications for understanding the evolution of bacterial regulatory networks, in particular, for the design of comparative studies of sRNA function. Here, we introduce relevant concepts from evolutionary biology and review recent work that has begun to shed light on the timescales and processes through which non-functional transcriptional noise is co-opted to provide regulatory functions. We explore possible scenarios for sRNA origin, focusing on the co-option, or exaptation, of existing genomic structures which may provide protected spaces for sRNA evolution.en_US
dc.language.isoenen_US
dc.publisherPortland Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbacteriaen_US
dc.subjectexaptationen_US
dc.subjectncRNAen_US
dc.subjectsRNAsen_US
dc.subjectselectionen_US
dc.subjecttranscriptional noiseen_US
dc.titleTranscriptional noise and exaptation as sources for bacterial sRNAs.en_US
dc.typeArticleen_US
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalBiochemical Society Transactionsen_US
dc.source.journaltitleBiochemical Society transactions


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Attribution-NonCommercial-ShareAlike 4.0 International
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