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Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus.

dc.contributor.authorSandargo, Birthe
dc.contributor.authorMichehl, Maira
dc.contributor.authorPraditya, Dimas
dc.contributor.authorSteinmann, Eike
dc.contributor.authorStadler, Marc
dc.contributor.authorSurup, Frank
dc.date.accessioned2019-06-05T08:00:25Z
dc.date.available2019-06-05T08:00:25Z
dc.date.issued2019-05-03
dc.identifier.citationOrg Lett. 2019 May 3;21(9):3286-3289. doi: 10.1021/acs.orglett.9b01017. Epub 2019 Apr 22.en_US
dc.identifier.issn1523-7052
dc.identifier.pmid31008606
dc.identifier.doi10.1021/acs.orglett.9b01017
dc.identifier.urihttp://hdl.handle.net/10033/621799
dc.description.abstractRhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleAntiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany; TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalOrganic Lettersen_US
dc.source.journaltitleOrganic letters


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