Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.
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Issue Date
2019-05-24
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Show full item recordAbstract
In our screening program for new biologically active secondary metabolites, a new strain, Nocardiopsis CG3 (DSM 106572), isolated from the saltpan of Kenadsa, was found to produce five new polyene macrolactams, the kenalactams A-E (1-5). Their structures were elucidated by spectral methods (NMR and HRESIMS), and the absolute configuration was derived by chemical derivatization (Mosher's method). Through a feeding experiment, alanine was proven to be the nitrogen-bearing starter unit involved in biosynthesis of the polyketide kenalactam A (1). Kenalactam E (5) was cytotoxic against human prostate cancer PC-3 cells with an IC50 value of 2.1 μM.Citation
Nat Prod. 2019 May 24;82(5):1081-1088. doi: 10.1021/acs.jnatprod.8b00708. Epub 2019 Apr 25.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
American Cemical Society (ACS)Journal
Journal of Natural ProductsPubMed ID
31021629Type
ArticleLanguage
enISSN
1520-6025ae974a485f413a2113503eed53cd6c53
10.1021/acs.jnatprod.8b00708
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