Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.

Messaoudi, Omar; Sudarman, Enge; Bendahou, Mourad; Jansen, Rolf; Stadler, Marc; Wink, Joachim

dc.contributor.author	Messaoudi, Omar
dc.contributor.author	Sudarman, Enge
dc.contributor.author	Bendahou, Mourad
dc.contributor.author	Jansen, Rolf
dc.contributor.author	Stadler, Marc
dc.contributor.author	Wink, Joachim
dc.date.accessioned	2019-06-21T11:30:00Z
dc.date.available	2019-06-21T11:30:00Z
dc.date.issued	2019-05-24
dc.identifier.citation	Nat Prod. 2019 May 24;82(5):1081-1088. doi: 10.1021/acs.jnatprod.8b00708. Epub 2019 Apr 25.	en_US
dc.identifier.issn	1520-6025
dc.identifier.pmid	31021629
dc.identifier.doi	10.1021/acs.jnatprod.8b00708
dc.identifier.uri	http://hdl.handle.net/10033/621823
dc.description.abstract	In our screening program for new biologically active secondary metabolites, a new strain, Nocardiopsis CG3 (DSM 106572), isolated from the saltpan of Kenadsa, was found to produce five new polyene macrolactams, the kenalactams A-E (1-5). Their structures were elucidated by spectral methods (NMR and HRESIMS), and the absolute configuration was derived by chemical derivatization (Mosher's method). Through a feeding experiment, alanine was proven to be the nitrogen-bearing starter unit involved in biosynthesis of the polyketide kenalactam A (1). Kenalactam E (5) was cytotoxic against human prostate cancer PC-3 cells with an IC50 value of 2.1 μM.	en_US
dc.language.iso	en	en_US
dc.publisher	American Cemical Society (ACS)	en_US
dc.rights	Attribution-NonCommercial-ShareAlike 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.	en_US
dc.type	Article	en_US
dc.contributor.department	HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.	en_US
dc.identifier.journal	Journal of Natural Products	en_US
dc.source.journaltitle	Journal of natural products