Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus.
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Issue Date
2019-05-24
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Show full item recordAbstract
During the course of searching for new anti-infective and other biologically active secondary metabolites from Kenyan basidiomycetes, 13 previously undescribed metabolites, (6 R,7 S,10 R)-7,10-epoxy-7,11-dimethyldodec-1-ene-6,11-diol (1) and 12 sesquiterpenes named elgonenes A-L (2-13), and the known compound P-coumaric acid (14) were isolated from a basidiomycete collected in Mount Elgon Natural Reserve. The producing organism represents a new species of the genus Sanghuangporus, which is one of the segregates of the important traditional Asian medicinal mushrooms that were formerly known as the " Inonotus linteus" complex. The structure elucidation of compounds 1-13, based on 2D NMR spectroscopy, high-resolution mass spectrometry, and other spectral methods, and their antibacterial, antifungal, and cytotoxic activities are reported.Citation
J Nat Prod. 2019 May 24;82(5):1283-1291. doi: 10.1021/acs.jnatprod.8b01086. Epub 2019 Apr 19.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
American Cemical Society (ACS)Journal
Journal of Natural ProductsPubMed ID
31001977Additional Links
ttps://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.8b01086Type
ArticleLanguage
enISSN
1520-6025ae974a485f413a2113503eed53cd6c53
10.1021/acs.jnatprod.8b01086
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