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dc.contributor.authorBaumann, Nicolas S
dc.contributor.authorWelten, Suzanne P M
dc.contributor.authorTorti, Nicole
dc.contributor.authorPallmer, Katharina
dc.contributor.authorBorsa, Mariana
dc.contributor.authorBarnstorf, Isabel
dc.contributor.authorOduro, Jennifer D
dc.contributor.authorCicin-Sain, Luka
dc.contributor.authorOxenius, Annette
dc.identifier.citationPLoS Pathog. 2019 May 13;15(5):e1007785. doi: 10.1371/journal.ppat.1007785. eCollection 2019 May.en_US
dc.description.abstractMemory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD8 T cell inflation in the context of MCMV infection. We found that the inflationary T cell pool comprised mainly high avidity CD8 T cells, outcompeting lower avidity CD8 T cells. Furthermore, the size of the inflationary T cell pool was not restricted by the availability of specific tissue niches, but it was directly related to the number of virus-specific CD8 T cells that were activated during priming. In particular, the amount of early-primed KLRG1- cells and the number of inflationary cells with a central memory phenotype were a critical determinant for the overall magnitude of the inflationary T cell pool. Inflationary memory CD8 T cells provided protection from a Vaccinia virus challenge and this protection directly correlated with the size of the inflationary memory T cell pool in peripheral tissues. These results highlight the remarkable protective potential of inflationary CD8 T cells that can be harnessed for CMV-based T cell vaccine approaches.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.titleEarly primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool.en_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalPLOS pathogensen_US
dc.source.journaltitlePLoS pathogens

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Attribution-NonCommercial-ShareAlike 4.0 International
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