• The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium.

      Luu, Maik; Romero, Rossana; Bazant, Jasmin; Abass, Elfadil; Hartmann, Sabrina; Leister, Hanna; Fischer, Florence; Mahdavi, Rouzbeh; Plaza-Sirvent, Carlos; Schmitz, Ingo; et al. (Wiley-VCH, 2019-11-14)
      Mice lacking CD4+ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.