Browsing publications of the AG system-oriented immunology and infection research (SIME) by Subjects
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The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium.Mice lacking CD4+ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.