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dc.contributor.authorAlfonso, J C L
dc.contributor.authorBerk, L
dc.date.accessioned2019-06-26T13:05:29Z
dc.date.available2019-06-26T13:05:29Z
dc.date.issued2019-05-30
dc.identifier.citationRadiat Oncol. 2019 May 30;14(1):88. doi: 10.1186/s13014-019-1288-y.en_US
dc.identifier.issn1748-717X
dc.identifier.pmid31146751
dc.identifier.doi10.1186/s13014-019-1288-y
dc.identifier.urihttp://hdl.handle.net/10033/621830
dc.description.abstractStandard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity. Therefore, a model with heterogeneity was developed and tested using existing experimental data to show the potential effects from the presence of an intratumoral distribution of radiosensitivity on radiation therapy response over a protracted radiation therapy treatment course.en_US
dc.language.isoenen_US
dc.publisherBioMed Central (BMC)en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAccelerated repopulationen_US
dc.subjectFractionated radiotherapyen_US
dc.subjectIntratumoral radiosensitivity heterogeneityen_US
dc.subjectLinear-quadratic modelen_US
dc.subjectRadiation resistanceen_US
dc.titleModeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy.en_US
dc.typeArticleen_US
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalRadiation Oncologyen_US
refterms.dateFOA2019-06-26T13:05:29Z
dc.source.journaltitleRadiation oncology (London, England)


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