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dc.contributor.authorSurup, Frank
dc.contributor.authorHennicke, Florian
dc.contributor.authorSella, Nadine
dc.contributor.authorStroot, Maria
dc.contributor.authorBernecker, Steffen
dc.contributor.authorPfütze, Sebastian
dc.contributor.authorStadler, Marc
dc.contributor.authorRühl, Martin
dc.date.accessioned2019-07-02T12:07:32Z
dc.date.available2019-07-02T12:07:32Z
dc.date.issued2019-01-01
dc.identifier.citationBeilstein J Org Chem. 2019 Apr 30;15:1000-1007. doi: 10.3762/bjoc.15.98. eCollection 2019.en_US
dc.identifier.issn1860-5397
dc.identifier.pmid31164938
dc.identifier.doi10.3762/bjoc.15.98
dc.identifier.urihttp://hdl.handle.net/10033/621838
dc.description.abstractThe strophariaceous basidiomycete Cyclocybe aegerita (synonyms Agrocybe aegerita and A. cylindracea) is one of the most praised cultivated edible mushrooms and is being cultivated at large scale for food production. Furthermore, the fungus serves as a model organism to study fruiting body formation and the production of secondary metabolites during the life cycle of Basidiomycota. By studying the secondary metabolite profiles of C. aegerita, we found several terpenoids in submerged cultures. Aside from the main metabolite, bovistol (1), two new bovistol derivatives B and C (2, 3) and pasteurestin C as a new protoilludane (4) were isolated by preparative HPLC. Their structures were elucidated by mass spectrometry and NMR spectroscopy. The relative configurations of 2-4 were assigned by ROESY correlations, and 3JH,H coupling constants in the case of 4. Applying quantitative PCR for gene expression validation, we linked the production of bovistol and its derivatives to the respective biosynthesis gene clusters.en_US
dc.publisherBeilstein Instituten_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbioinformaticsen_US
dc.subjectgene cluster analysisen_US
dc.subjectnatural productsen_US
dc.subjectsecondary metabolitesen_US
dc.subjectstructure elucidationen_US
dc.subjectterpenesen_US
dc.titleNew terpenoids from the fermentation broth of the edible mushroom .en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalBeilstein Journal of Organic Chemistryen_US
refterms.dateFOA2019-07-02T12:07:33Z
dc.source.journaltitleBeilstein journal of organic chemistry


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