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dc.contributor.authorMeister, Toni Luise
dc.contributor.authorTegtmeyer, Birthe
dc.contributor.authorPostel, Alexander
dc.contributor.authorCavalleri, Jessika-M V
dc.contributor.authorTodt, Daniel
dc.contributor.authorStang, Alexander
dc.contributor.authorSteinmann, Eike
dc.date.accessioned2019-07-02T13:16:22Z
dc.date.available2019-07-02T13:16:22Z
dc.date.issued2019-05-21
dc.identifier.citationViruses. 2019 May 21;11(5). pii: v11050461. doi: 10.3390/v11050461.en_US
dc.identifier.issn1999-4915
dc.identifier.pmid31117220
dc.identifier.doi10.3390/v11050461
dc.identifier.urihttp://hdl.handle.net/10033/621841
dc.description.abstractAn equine parvovirus-hepatitis (EqPV-H) has been recently identified in association with equine serum hepatitis, also known as Theiler's disease. This disease was first described by Arnold Theiler in 1918 and is often observed after applications with blood products in equines. So far, the virus has only been described in the USA and China. In this study, we evaluated the presence of EqPV-H in several commercial serum samples to assess the potential risk of virus transmission by equine serum-based products for medical and research applications. In 11 out of 18 commercial serum samples, EqPV-H DNA was detectable with a viral load up to 105 copies/mL. The same serum batches as well as three additional samples were also positive for antibodies against the EqPV-H VP1 protein. The countries of origin with detectable viral genomes included the USA, Canada, New Zealand, Italy, and Germany, suggesting a worldwide distribution of EqPV-H. Phylogenetic analysis of the EqPV-H NS1 sequence in commercial serum samples revealed high similarities in viral sequences from different geographical areas. As horse sera are commonly used for the production of anti-sera, which are included in human and veterinary medical products, these results implicate the requirement for diagnostic tests to prevent EqPV-H transmission.en_US
dc.language.isoenen_US
dc.publisherMPDIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectcommercial horse serumen_US
dc.subjectequine parvovirus-hepatitisen_US
dc.subjecthorsesen_US
dc.subjectphylogenyen_US
dc.titleEquine Parvovirus-Hepatitis Frequently Detectable in Commercial Equine Serum Pools.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalVirusesen_US
dc.source.journaltitleViruses


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