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dc.contributor.authorHartman, Alwin M.
dc.contributor.authorGierse, Robin M.
dc.contributor.authorHirsch, Anna K. H.
dc.date.accessioned2019-07-04T12:52:19Z
dc.date.available2019-07-04T12:52:19Z
dc.date.issued2019-05-03
dc.identifier.urihttp://hdl.handle.net/10033/621846
dc.description.abstractDynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives. An ever‐increasing number of publications report the use of DCC on biologically relevant target proteins. This minireview complements previous reviews by focusing on the experimental protocol and giving detailed examples of essential steps and factors that need to be considered, such as protein stability, buffer composition and cosolvents.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleProtein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocolen_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalEuropean Journal of Organic Chemistryen_US
refterms.dateFOA2019-07-04T12:52:19Z


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