• IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.

      Zhang, Zhenhua; Trypsteen, Wim; Blaauw, Marc; Chu, Xiaojing; Rutsaert, Sofie; Vandekerckhove, Linos; van der Heijden, Wouter; Dos Santos, Jéssica Cristina; Xu, Cheng-Jian; Swertz, Morris A; et al. (BMC, 2021-11-16)
      The analysis resulted in one significant association with CA HIV-1 DNA (rs2613996, P < 5 × 10-8) and two suggestive associations with RNA:DNA ratio (rs7113204 and rs7817589, P < 5 × 10-7). Then, we prioritized PTDSS2, IRF7, RNH1, and DEAF1 as potential HIV-1 reservoir modifiers and validated that higher expressions of IRF7 and RNH1 were accompanied by rs7113204-G. Moreover, RNA:DNA ratio, indicating relative HIV-1 transcription activity, was lower in PLHIV carrying this variant.