Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractMammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and complex interactions resulting in important functional consequences. These interactions govern immune homeostasis, host response to infection, vaccination and cancer, as well as predisposition to metabolic, inflammatory and neurological disorders. Here, we discuss recent studies on direct and indirect effects of resident microbiota on regulatory T cells (Tregs) and Th17 cells at the cellular and molecular level. We review mechanisms by which commensal microbes influence mucosa in the context of bioactive molecules derived from resident bacteria, immune senescence, chronic inflammation and cancer. Lastly, we discuss potential therapeutic applications of microbiota alterations and microbial derivatives, for improving resilience of mucosal immunity and combating immunopathology.
CitationFront Immunol. 2019 Mar 8;10:426. doi: 10.3389/fimmu.2019.00426. eCollection 2019.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
JournalFrontiers in immunology
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Role of Short Chain Fatty Acids in Controlling T<sub>regs</sub> and Immunopathology During Mucosal Infection.
- Authors: Bhaskaran N, Quigley C, Paw C, Butala S, Schneider E, Pandiyan P
- Issue date: 2018
- The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome.
- Authors: Omenetti S, Pizarro TT
- Issue date: 2015
- Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases.
- Authors: Tlaskalová-Hogenová H, Stepánková R, Hudcovic T, Tucková L, Cukrowska B, Lodinová-Zádníková R, Kozáková H, Rossmann P, Bártová J, Sokol D, Funda DP, Borovská D, Reháková Z, Sinkora J, Hofman J, Drastich P, Kokesová A
- Issue date: 2004 May 15
- Type 3 regulatory T cells at the interface of symbiosis.
- Authors: Park JH, Eberl G
- Issue date: 2018 Mar
- Circulating and Tissue-Resident CD4<sup>+</sup> T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
- Authors: Hegazy AN, West NR, Stubbington MJT, Wendt E, Suijker KIM, Datsi A, This S, Danne C, Campion S, Duncan SH, Owens BMJ, Uhlig HH, McMichael A, Oxford IBD Cohort Investigators., Bergthaler A, Teichmann SA, Keshav S, Powrie F
- Issue date: 2017 Nov