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dc.contributor.authorPandiyan, Pushpa
dc.contributor.authorBhaskaran, Natarajan
dc.contributor.authorZou, Mangge
dc.contributor.authorSchneider, Elizabeth
dc.contributor.authorJayaraman, Sangeetha
dc.contributor.authorHuehn, Jochen
dc.date.accessioned2019-07-15T09:51:16Z
dc.date.available2019-07-15T09:51:16Z
dc.date.issued2019-01-01
dc.identifier.citationFront Immunol. 2019 Mar 8;10:426. doi: 10.3389/fimmu.2019.00426. eCollection 2019.en_US
dc.identifier.issn1664-3224
dc.identifier.pmid30906299
dc.identifier.doi10.3389/fimmu.2019.00426
dc.identifier.urihttp://hdl.handle.net/10033/621874
dc.description.abstractMammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and complex interactions resulting in important functional consequences. These interactions govern immune homeostasis, host response to infection, vaccination and cancer, as well as predisposition to metabolic, inflammatory and neurological disorders. Here, we discuss recent studies on direct and indirect effects of resident microbiota on regulatory T cells (Tregs) and Th17 cells at the cellular and molecular level. We review mechanisms by which commensal microbes influence mucosa in the context of bioactive molecules derived from resident bacteria, immune senescence, chronic inflammation and cancer. Lastly, we discuss potential therapeutic applications of microbiota alterations and microbial derivatives, for improving resilience of mucosal immunity and combating immunopathology.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectTh17en_US
dc.subjectTregen_US
dc.subjectantibioticsen_US
dc.subjectinflammationen_US
dc.subjectmicrobiomeen_US
dc.subjectmucosaen_US
dc.subjectmucosal immunityen_US
dc.subjectresident microbesen_US
dc.titleMicrobiome Dependent Regulation of Tregs and Th17 Cells in Mucosa.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in immunologyen_US
refterms.dateFOA2019-07-15T09:51:16Z
dc.source.journaltitleFrontiers in immunology


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Attribution-NonCommercial-ShareAlike 4.0 International
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