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dc.contributor.authorTegtmeyer, Pia-Katharina
dc.contributor.authorSpanier, Julia
dc.contributor.authorBorst, Katharina
dc.contributor.authorBecker, Jennifer
dc.contributor.authorRiedl, André
dc.contributor.authorHirche, Christoph
dc.contributor.authorGhita, Luca
dc.contributor.authorSkerra, Jennifer
dc.contributor.authorBaumann, Kira
dc.contributor.authorLienenklaus, Stefan
dc.contributor.authorDoering, Marius
dc.contributor.authorRuzsics, Zsolt
dc.contributor.authorKalinke, Ulrich
dc.date.accessioned2019-07-15T13:21:30Z
dc.date.available2019-07-15T13:21:30Z
dc.date.issued2019-06-27
dc.identifier.citationNat Commun. 2019 Jun 27;10(1):2830. doi: 10.1038/s41467-019-10863-0.en_US
dc.identifier.issn2041-1723
dc.identifier.pmid31249303
dc.identifier.doi10.1038/s41467-019-10863-0
dc.identifier.urihttp://hdl.handle.net/10033/621875
dc.description.abstractCytomegalovirus is a DNA-encoded β-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as a vehicle for dissemination. Here we report that STING knockout mice are as resistant to murine cytomegalovirus (MCMV) infection as wild-type controls, whereas mice with a combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency do not mount type 1 interferon responses and succumb to the infection. Although STING alone is dispensable for survival, early IFN-β induction in Kupffer cells is STING-dependent and controls early hepatic virus propagation. Infection experiments with an inducible reporter MCMV show that STING constrains MCMV replication in myeloid cells and limits viral dissemination via these cells. By contrast, restriction of viral dissemination from hepatocytes to other organs is independent of STING. Thus, during MCMV infection STING is involved in early IFN-β induction in Kupffer cells and the restriction of viral dissemination via myeloid cells, whereas it is dispensable for survival.en_US
dc.language.isoenen_US
dc.publisherSpringer-Natureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleSTING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalNature Communicationsen_US
refterms.dateFOA2019-07-15T13:21:31Z
dc.source.journaltitleNature communications


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Attribution-NonCommercial-ShareAlike 4.0 International
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