Myeloid-Derived Suppressor Cells in Infection: A General Overview.
Abstract
After initial infection, the immune response that serves to restrict the invading pathogen needs to be tightly calibrated in order to avoid collateral immunopathological damage. This calibration is performed by specialized suppressor mechanisms, which are capable of dampening overwhelming or unremitting inflammation in order to prevent tissue damage. Myeloid-derived suppressor cells (MDSC) are emerging as key players in counter-balancing inflammatory responses and pathogenesis during infection. However, some pathogens are able to exploit the suppressive activities of MDSC to favor pathogen persistence and chronic infections. In this article, we review the current knowledge about the importance of MDSC in the context of bacterial, virus, parasites, and fungal infections.Citation
J Innate Immun. 2018;10(5-6):407-413. doi: 10.1159/000489830. Epub 2018 Jun 26.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
KargerJournal
Journal of Innate ImmunityPubMed ID
29945134Type
ArticleLanguage
enISSN
1662-8128Scopus Count
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- Creative Commons
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