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dc.contributor.authorChepkirui, Clara
dc.contributor.authorMatasyoh, Josphat, C.
dc.contributor.authorDecock, Cony, A.
dc.contributor.authorStadler, Marc
dc.date.accessioned2019-07-18T12:22:17Z
dc.date.available2019-07-18T12:22:17Z
dc.date.issued2017-04-26
dc.identifier.issn18743900
dc.identifier.doi10.1016/j.phytol.2017.04.009
dc.identifier.urihttp://hdl.handle.net/10033/621882
dc.description.abstractHPLC profiling of the mycelial culture of a poroid basidomycete collected in Mount Elgon, Kenya, which probably represents a new species of the genus Laetiporus, led to isolation of two previously undescribed lanostane type triterpenes.We propose the trivial names laetiporins A (1) and B (2). In addition, five known ones: dehydrosulphurenic acid (3), sulphurenic acid (4), eburicoic acid (5), 15α-hydroxytrametenolic acid (6) and trametenolic acid (7) were also isolated. The laetiporins (1–2) exhibited significant cytotoxic effects against various human cancer cells. The known compounds (3–5) and (7) also showed moderate cytotoxic activity, but none of the compounds showed any significant antimicrobial activity.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCytotoxicityen_US
dc.subjectFungien_US
dc.subjectPolyporalesen_US
dc.subjectTerpenoidsen_US
dc.titleTwo cytotoxic triterpenes from cultures of a Kenyan Laetiporus sp. (Basidiomycota)en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalPhytochemistry Lettersen_US
refterms.dateFOA2019-07-18T12:22:17Z


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