Show simple item record

dc.contributor.authorCañete, Pablo F
dc.contributor.authorSweet, Rebecca A
dc.contributor.authorGonzalez-Figueroa, Paula
dc.contributor.authorPapa, Ilenia
dc.contributor.authorOhkura, Naganari
dc.contributor.authorBolton, Holly
dc.contributor.authorRoco, Jonathan A
dc.contributor.authorCuenca, Marta
dc.contributor.authorBassett, Katharine J
dc.contributor.authorSayin, Ismail
dc.contributor.authorBarry, Emma
dc.contributor.authorLopez, Angel
dc.contributor.authorCanaday, David H
dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorDoglioni, Claudio
dc.contributor.authorFazekas de St Groth, Barbara
dc.contributor.authorSakaguchi, Shimon
dc.contributor.authorCook, Matthew C
dc.contributor.authorVinuesa, Carola G
dc.identifier.citationJ Exp Med. 2019 Jun 17. pii: jem.20190493. doi: 10.1084/jem.20190493.en_US
dc.description.abstractMucosal lymphoid tissues such as human tonsil are colonized by bacteria and exposed to ingested and inhaled antigens, requiring tight regulation of immune responses. Antibody responses are regulated by follicular helper T (TFH) cells and FOXP3+ follicular regulatory T (TFR) cells. Here we describe a subset of human tonsillar follicular T cells identified by expression of TFH markers and CD25 that are the main source of follicular T (TF) cell-derived IL-10. Despite lack of FOXP3 expression, CD25+ TF cells resemble T reg cells in high CTLA4 expression, low IL-2 production, and their ability to repress T cell proliferation. CD25+ TF cell-derived IL-10 dampens induction of B cell class-switching to IgE. In children, circulating total IgE titers were inversely correlated with the frequencies of tonsil CD25+ TF cells and IL-10-producing TF cells but not with total T reg cells, TFR, or IL-10-producing T cells. Thus, CD25+ TF cells emerge as a subset with unique T and B cell regulatory activities that may help prevent atopy.en_US
dc.publisherRockefeller University Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.titleRegulatory roles of IL-10-producing human follicular T cells.en_US
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalJournal of experimental Medicineen_US
dc.source.journaltitleThe Journal of experimental medicine

Files in this item

Canete et al.pdf
Open Access article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International