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dc.contributor.authorNaini, Arun
dc.contributor.authorSasse, Florenz
dc.contributor.authorBrönstrup, Mark
dc.date.accessioned2019-08-05T10:57:29Z
dc.date.available2019-08-05T10:57:29Z
dc.date.issued2019-04-05
dc.identifier.citationNat Prod Rep. 2019 Apr 5. doi: 10.1039/c9np00008a.en_US
dc.identifier.issn1460-4752
dc.identifier.pmid30950477
dc.identifier.doi10.1039/c9np00008a
dc.identifier.urihttp://hdl.handle.net/10033/621893
dc.description.abstractCovering: up to the end of 2018Soraphens are a class of polyketide natural products discovered from the myxobacterial strain Sorangium cellulosum. The review is intended to provide an overview on the biosynthesis, chemistry and biological properties of soraphens, that represent a prime example to showcase the value of natural products as tools to decipher cell biology, but also to open novel therapeutic options. The prototype soraphen A is an inhibitor of acetyl coenzyme A carboxylase (ACC1/2), an enzyme that converts acetyl-CoA to malonyl-CoA and thereby controls essential cellular metabolic processes like lipogenesis and fatty acid oxidation. Soraphens illustrate how the inhibition of a single target (ACC1/2) may be explored to treat various pathological conditions: initially developed as a fungicide, efforts in the past decade were directed towards human diseases, including diabetes/obesity, cancer, hepatitis C, HIV, and autoimmune disease - and led to a synthetic molecule, discovered by virtual screening of the allosteric binding site of soraphen in ACC, that is currently in phase 2 clinical trials. We will summarize how structural analogs of soraphen A have been generated through extensive isolation efforts, genetic engineering of the biosynthetic gene cluster, semisynthesis as well as partial and total synthesis.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleThe intriguing chemistry and biology of soraphens.en_US
dc.typeArticleen_US
dc.identifier.journalNatural Product Reports en_US
dc.source.journaltitleNatural product reports


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Attribution-NonCommercial-ShareAlike 4.0 International
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