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dc.contributor.authorTang, Dan
dc.contributor.authorXu, Yuan-Zhen
dc.contributor.authorWang, Wei-Wei
dc.contributor.authorYang, Zhi
dc.contributor.authorLiu, Bo
dc.contributor.authorStadler, Marc
dc.contributor.authorLiu, Ling-Li
dc.contributor.authorGao, Jin-Ming
dc.date.accessioned2019-08-12T08:46:51Z
dc.date.available2019-08-12T08:46:51Z
dc.date.issued2019-06-18
dc.identifier.citationJ Nat Prod. 2019 Jun 18. doi: 10.1021/acs.jnatprod.9b00091.en_US
dc.identifier.issn1520-6025
dc.identifier.pmid31244147
dc.identifier.doi10.1021/acs.jnatprod.9b00091
dc.identifier.urihttp://hdl.handle.net/10033/621894
dc.description.abstractSix new cyathane diterpenoids, cyahookerins A-F (1-6), as well as nine known analogues (7-15), were isolated from the liquid culture of the basidiomycete Cyathus hookeri. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, and ECD), and the absolute configurations of compounds 1 and 4 were determined by single-crystal X-ray crystallography. Compounds 1 and 2 represent the first unusual cyathane acetals featuring a dioxolane ring. Compounds 1-6 displayed differential nerve growth factor-induced neurite outgrowth-promoting activity in PC-12 cells at concentrations of 10 μM. In addition, cyahookerin B (2), cyathin E (9), cyathin B2 (12), and cyathin Q (13) showed significant nitric oxide production inhibition in Lipopolysaccharide (LPS)-activated BV-2 microglial cells with IC50 values of 12.0, 6.9, 10.9, and 9.1 μM, respectively. Similar binding modes of the four compounds were indicated by molecular-docking studies, and structure-activity relationships are discussed.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleCyathane Diterpenes from Cultures of the Bird's Nest Fungus Cyathus hookeri and Their Neurotrophic and Anti-neuroinflammatory Activities.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournal of natural productsen_US
dc.source.journaltitleJournal of natural products


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