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dc.contributor.authorPesarrodona, Mireia
dc.contributor.authorJauset, Toni
dc.contributor.authorDíaz-Riascos, Zamira V.
dc.contributor.authorSánchez-Chardi, Alejandro
dc.contributor.authorBeaulieu, Marie Eve
dc.contributor.authorSeras-Franzoso, Joaquin
dc.contributor.authorSánchez-García, Laura
dc.contributor.authorBaltà-Foix, Ricardo
dc.contributor.authorMancilla, Sandra
dc.contributor.authorFernández, Yolanda
dc.contributor.authorRinas, Ursula
dc.contributor.authorSchwartz, Simó
dc.contributor.authorSoucek, Laura
dc.contributor.authorVillaverde, Antonio
dc.contributor.authorAbasolo, Ibane
dc.contributor.authorVázquez, Esther
dc.creatorPesarrodona, M.
dc.date.accessioned2019-08-15T14:33:45Z
dc.date.available2019-08-15T14:33:45Z
dc.date.issued2019-01-01
dc.identifier.doi10.1002/advs.201900849
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069946471&origin=inward
dc.identifier.urihttp://hdl.handle.net/10033/621903
dc.description.abstractTwo structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteinsen_US
dc.language.isoenen_US
dc.publisherWiley-VCHen_US
dc.relation.ispartofAdvanced Science
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbiofabricationen_US
dc.subjectcancer therapyen_US
dc.subjectfunctional amyloidsen_US
dc.subjectinclusion bodiesen_US
dc.subjectprotein drug releaseen_US
dc.titleTargeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodiesen_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalAdvanced Scienceen_US
dc.identifier.eid2-s2.0-85069946471
dc.identifier.scopusidSCOPUS_ID:85069946471
refterms.dateFOA2019-08-15T14:33:46Z


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