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dc.contributor.authorSchuster, Marc
dc.contributor.authorPlaza-Sirvent, Carlos
dc.contributor.authorVisekruna, Alexander
dc.contributor.authorHuehn, Jochen
dc.contributor.authorSchmitz, Ingo
dc.date.accessioned2019-08-20T13:39:56Z
dc.date.available2019-08-20T13:39:56Z
dc.date.issued2019-01-01
dc.identifier.issn1664-3224
dc.identifier.pmid31354726
dc.identifier.doi10.3389/fimmu.2019.01583
dc.identifier.urihttp://hdl.handle.net/10033/621911
dc.description.abstractNext to the classical developmental route, in which first CD25 and subsequently Foxp3 are induced to generate thymic regulatory T (Treg) cells, an alternative route has been described. This alternative route is characterized by reciprocal induction of Foxp3 and CD25, with CD25 induction being required to rescue developing Treg cells from Foxp3-induced apoptosis. NF-κB has been demonstrated to be crucial for the development of thymic Treg cells via the classical route. However, its impact on the alternative route is poorly characterized. Using single and double deficient mice for key regulators of the classical route, c-Rel and IκBNS, we here demonstrate that NF-κB is essential for the generation of alternative CD25-Foxp3+ precursors, as well. Thus, c-Rel and IκBNS govern both routes of thymic Treg cell development.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectNF-κBen_US
dc.subjectcell differentiationen_US
dc.subjectcommon γ-chain cytokinesen_US
dc.subjectregulatory T cellen_US
dc.subjectthymusen_US
dc.subjecttranscription factoren_US
dc.titleGeneration of Foxp3CD25 Regulatory T-Cell Precursors Requires c-Rel and IκB.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in Immunologyen_US
refterms.dateFOA2019-08-20T13:39:57Z
dc.source.journaltitleFrontiers in immunology


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