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dc.contributor.authorAkmatov, Manas K
dc.contributor.authorRiese, Peggy
dc.contributor.authorTrittel, Stephanie
dc.contributor.authorMay, Marcus
dc.contributor.authorProkein, Jana
dc.contributor.authorIllig, Thomas
dc.contributor.authorSchindler, Christoph
dc.contributor.authorGuzmán, Carlos A
dc.contributor.authorPessler, Frank
dc.date.accessioned2019-08-21T10:41:11Z
dc.date.available2019-08-21T10:41:11Z
dc.date.issued2019-07-23
dc.identifier.citationBMC Infect Dis. 2019 Jul 23;19(1):656. doi: 10.1186/s12879-019-4214-x.en_US
dc.identifier.issn1471-2334
dc.identifier.pmid31337344
dc.identifier.doi10.1186/s12879-019-4214-x
dc.identifier.urihttp://hdl.handle.net/10033/621914
dc.description.abstractBACKGROUND: The immune response to seasonal influenza vaccines decreases with advancing age. Therefore, an adjuvanted inactivated trivalent influenza vaccine (Fluad®) exists for elderly individuals. Fluad® is more immunogenic and efficacious than conventional influenza vaccines. However, the immune response varies and may still result in high frequencies of poor responders. Therefore, we aimed to a) examine the prevalence of a weak response to Fluad® and b) identify potential risk factors. METHODS: A prospective population-based study among individuals 65-80 years old was conducted in 2015/2016 in Hannover, Germany (n = 200). Hemagglutination-inhibition titers 21 days after vaccination with Fluad® served as indicator of vaccine responsiveness. RESULTS: The percentage of vaccinees with an inadequate vaccine response varied depending on the influenza strain: it was lowest for H3N2 (13.5%; 95% CI, 9.4-18.9%), intermediate for B strain (37.0%; 30.6-43.9%), and highest for H1N1 (49.0%; 42.2-55.9%). The risk of a weak response to the influenza A H1N1 strain was independently associated with self-reported diabetes (AOR, 4.64; 95% CI, 1.16-18.54), a history of herpes zoster (2.27; 1.01-5.10) and, to a much lesser extent, increasing age (change per year, 1.08; 0.99-1.16). In addition, herpes zoster was the only risk factor for a weak response to the H3N2 antigen (AOR, 3.12; 1.18-8.23). We found no significant association between sex, Body Mass Index, cancer, hypertension, heart attack and CMV seropositivity and a weak response to these two influenza A antigens. Despite its occurence in over one third of vaccinees, none of the variables examined proved to be risk factors for a weak response to the B antigen. CONCLUSIONS: A considerable proportion of elderly individuals displayed a weak vaccine response to this adjuvanted seasonal influenza vaccine and further efforts are thus needed to improve immune responses to influenza vaccination among the elderly. Diabetes and herpes zoster were identified as potentially modifiable risk factors for a poor vaccine response against influenza A antigens, but the results also reveal the need for broader investigations to identify risk factors for inadequate responses to influenza B antigens.en_US
dc.language.isoenen_US
dc.publisherBioMedCentralen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectDiabetesen_US
dc.subjectElderlyen_US
dc.subjectFluad®en_US
dc.subjectHerpes zosteren_US
dc.subjectInfluenza vaccinationen_US
dc.titleSelf-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalBMC Infectious Diseasesen_US
refterms.dateFOA2019-08-21T10:41:12Z
dc.source.journaltitleBMC infectious diseases


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