Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Caputo, MahrrouzRaupach-Rosin, Heike
Karch, André

Borte, Michael
Lehmann, Irina
Liebert, Uwe Gerd
Standl, Marie
Heinrich, Joachim
Mikolajczyk, Rafael T
Issue Date
2019-01-01
Metadata
Show full item recordAbstract
The evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the population-based birth cohort study LISA conducted in Germany to explore whether routine childhood vaccinations and the individual infection history in the first 2 years of life are associated with unrelated antibody titers. We selected 19 exposures (infections and vaccinations) and investigated their association with levels of 12 IgG antibody titers at the age of 2 years. Based on univariable analyses (ANOVA), we identified 21 crude associations between exposures and titers (p < 0.05), while 11 (95%-CI: 6, 17) spurious associations were expected due to multiple testing. In exploratory multivariable analyses, we observed associations between seven investigated IgG titers and 10 exposures; either administered vaccines [e.g., higher anti-hRSV IgG titer in BCG-vaccinated children (regression-coefficient in standard-deviation-units: 0.38; 95%-CI: 0.12, 0.65)] or infections [e.g., higher anti-measles IgG titer in children with reported chickenpox (0.44; 95%-CI: 0.08, 0.80)]. Our results indicate the existence of associations between immunogenic exposures and unrelated antibody titers. Further studies investigating the underlying immunological mechanisms are required.Citation
Front Pediatr. 2019 Jun 25;7:254. doi: 10.3389/fped.2019.00254. eCollection 2019.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
FrontiersJournal
Frontiers in PediatricsPubMed ID
31294004Type
ArticleLanguage
enISSN
2296-2360ae974a485f413a2113503eed53cd6c53
10.3389/fped.2019.00254
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
Related articles
- A Survey of Vaccine-Induced Measles IgG Antibody Titer to Verify Temporal Changes in Response to Measles Vaccination in Young Adults.
- Authors: Sasaki H, Fukunaga T, Asano A, Suzuki Y, Nakanishi Y, Kondo J, Ishikawa H, Shibata N
- Issue date: 2019 Sep 19
- Exposure to lead and vaccine-specific IgG titers in South African children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE): A longitudinal study.
- Authors: Di Lenardo TZ, Ward BJ, Pillet S, Mann K, Bornman R, Obida M, Chevrier J
- Issue date: 2020 Jan
- Divergent mortality for male and female recipients of low-titer and high-titer measles vaccines in rural Senegal.
- Authors: Aaby P, Samb B, Simondon F, Knudsen K, Seck AM, Bennett J, Whittle H
- Issue date: 1993 Nov 1
- Prospective Study of Live Attenuated Vaccines for Patients with Nephrotic Syndrome Receiving Immunosuppressive Agents.
- Authors: Kamei K, Miyairi I, Ishikura K, Ogura M, Shoji K, Funaki T, Ito R, Arai K, Abe J, Kawai T, Onodera M, Ito S
- Issue date: 2018 May
- Influence of MMR-vaccinations and diseases on atopic sensitization and allergic symptoms in Swiss schoolchildren.
- Authors: Roost HP, Gassner M, Grize L, Wüthrich B, Sennhauser FH, Varonier HS, Zimmermann H, Braun-Fahrländer Ch, SCARPOL-team
- Issue date: 2004 Oct