Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Ho, Duy-KhietNichols, Brittany L B
Edgar, Kevin J
Murgia, Xabier
Loretz, Brigitta
Lehr, Claus-Michael
Issue Date
2019-09-04
Metadata
Show full item recordAbstract
Inhalation therapy has been reported as the most effective treatment for respiratory bacterial infections due to the increasing relevance of drug bioavailability. Drug delivery systems (DDS) have the capacity to overcome pulmonary biological barriers limiting the bioavailability of inhaled anti-infectives. This is important to eradicate bacterial infections and to prevent the development of bacterial resistance. Despite substantial efforts in the field, the current state-of-the-art often fails to achieve those goals, and we still observe increasing bacterial resistance. We give a brief insight on benefits and challenges in pulmonary delivery of anti-infectives. In the context of drug delivery development for pulmonary infections, particularly focusing on Pseudomonas aeruginosa (PA) infections, this mini review will critically discuss the main requirements, as well as the recent strategies of drug delivery system synthesis and preparation. Finally, interaction of DDS with crucial pulmonary biological barriers will be of great importance for the success of future applications of the developed DDS.Citation
Eur J Pharm Biopharm. 2019 Sep 4. pii: S0939-6411(19)30620-4. doi: 10.1016/j.ejpb.2019.09.002.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
ElsevierPubMed ID
31493510Type
ArticleLanguage
enISSN
1873-3441ae974a485f413a2113503eed53cd6c53
10.1016/j.ejpb.2019.09.002
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
Related articles
- Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.
- Authors: Nafee N, Husari A, Maurer CK, Lu C, de Rossi C, Steinbach A, Hartmann RW, Lehr CM, Schneider M
- Issue date: 2014 Oct 28
- A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections.
- Authors: Merchant Z, Buckton G, Taylor KM, Stapleton P, Saleem IY, Zariwala MG, Somavarapu S
- Issue date: 2016
- Liposomal antibiotic formulations for targeting the lungs in the treatment of Pseudomonas aeruginosa.
- Authors: Alipour M, Suntres ZE
- Issue date: 2014 Apr
- Challenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis.
- Authors: Greally P, Whitaker P, Peckham D
- Issue date: 2012 Jun
- Aspects of pulmonary drug delivery strategies for infections in cystic fibrosis--where do we stand?
- Authors: Klinger-Strobel M, Lautenschläger C, Fischer D, Mainz JG, Bruns T, Tuchscherr L, Pletz MW, Makarewicz O
- Issue date: 2015 Aug