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dc.contributor.authorTegtmeyer, Birthe
dc.contributor.authorEchelmeyer, Julia
dc.contributor.authorPfankuche, Vanessa M
dc.contributor.authorPuff, Christina
dc.contributor.authorTodt, Daniel
dc.contributor.authorFischer, Nicole
dc.contributor.authorDurham, Andy
dc.contributor.authorFeige, Karsten
dc.contributor.authorBaumgärtner, Wolfgang
dc.contributor.authorSteinmann, Eike
dc.contributor.authorCavalleri, Jessika-M V
dc.date.accessioned2019-09-18T13:03:42Z
dc.date.available2019-09-18T13:03:42Z
dc.date.issued2019-01-01
dc.identifier.citationVet Med Sci. 2019 Aug;5(3):372-378. doi: 10.1002/vms3.181. Epub 2019 Jul 3.en_US
dc.identifier.issn2053-1095
dc.identifier.pmid31267690
dc.identifier.doi10.1002/vms3.181
dc.identifier.urihttp://hdl.handle.net/10033/621950
dc.description.abstractBackground: Equine hepacivirus (EqHV) in equids represents the closest homologue to hepatitis C virus(HCV) infecting humans. A majority of HCV infected patients develop a chronic course of infection leading toliver fibrosis, cirrhosis and liver failure. However, in horses mostly transient mild subclinical infections arereported for EqHV to date. Objectives: EqHV can be involved in chronic liver diseases of horses. Methods:Biochemical parameters in serum samples were measured. Viral load was determined using qPCR. Next gener-ation sequencing (NGS) of serum was performed. Liver tissue was stained with haematoxylin and eosin andanalysed for viral RNA with fluorescentin situ-hybridization. Results: The horse showed symptoms of severehepatopathy and was chronically infected with EqHV. Viral RNA was detectable in the liver during disease.To rule out other infectious agents NGS was performed and showed the highest abundance for EqHV. Theidentified virus sequence was similar to other circulating equine hepaciviruses. Conclusions: EqHV can be asso-ciated with liver disease in horses. Whether it causes the disease or contributes in a multifactorial mannerneeds further investigationen_US
dc.language.isoenen_US
dc.publisherWiley Open Accessen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/ 643476en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectequine hepacivirusen_US
dc.subjecthepacivirus Aen_US
dc.subjecthepatitis C virusen_US
dc.subjecthepatopathyen_US
dc.subjectliveren_US
dc.titleChronic equine hepacivirus infection in an adult gelding with severe hepatopathy.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalVeterinary Medicine and Scienceen_US
dc.source.journaltitleVeterinary medicine and science


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