Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractCell migration is an essential process, both in unicellular organisms such as amoeba and as individual or collective motility in highly developed multicellular organisms like mammals. It is controlled by a variety of activities combining protrusive and contractile forces, normally generated by actin filaments. Here, we summarize actin filament assembly and turnover processes, and how respective biochemical activities translate into different protrusion types engaged in migration. These actin-based plasma membrane protrusions include actin-related protein 2/3 complex-dependent structures such as lamellipodia and membrane ruffles, filopodia as well as plasma membrane blebs. We also address observed antagonisms between these protrusion types, and propose a model – also inspired by previous literature – in which a complex balance between specific Rho GTPase signaling pathways dictates the protrusion mechanism employed by cells. Furthermore, we revisit published work regarding the fascinating antagonism between Rac and Rho GTPases, and how this intricate signaling network can define cell behavior and modes of migration. Finally, we discuss how the assembly of actin filament networks can feed back onto their regulators, as exemplified for the lamellipodial factor WAVE regulatory complex, tightly controlling accumulation of this complex at specific subcellular locations as well as its turnover.
CitationEssays Biochem. 2019 Sep 24. pii: EBC20190015. doi: 10.1042/EBC20190015.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
PublisherPortland Press Ltd.
JournalEssays in Biochemistry
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly.
- Authors: Dimchev G, Steffen A, Kage F, Dimchev V, Pernier J, Carlier MF, Rottner K
- Issue date: 2017 May 15
- Assembling actin filaments for protrusion.
- Authors: Rottner K, Schaks M
- Issue date: 2019 Feb
- Lamellipodia-like actin networks in cells lacking WAVE regulatory complex.
- Authors: Kage F, Döring H, Mietkowska M, Schaks M, Grüner F, Stahnke S, Steffen A, Müsken M, Stradal TEB, Rottner K
- Issue date: 2022 Aug 1
- Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration.
- Authors: Mehidi A, Kage F, Karatas Z, Cercy M, Schaks M, Polesskaya A, Sainlos M, Gautreau AM, Rossier O, Rottner K, Giannone G
- Issue date: 2021 Nov
- Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization.
- Authors: Machesky LM, Hall A
- Issue date: 1997 Aug 25