Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses.
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AbstractThe germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using an agent-based model of the germinal center reaction, we studied the impact of antibody feedback on kinetics and efficiency of a germinal center. Our simulations predict that high feedback of antibodies from germinal centers reduces the production of plasma cells and subsequently the efficiency of the germinal center reaction by promoting earlier termination. Affinity maturation is only weakly improved by increased antibody feedback and ultimately interrupted because of premature termination of the reaction. The model predicts that the asynchronous onset and changes in number of germinal centers could alter the efficiency of antibody response due to changes in feedback by soluble antibodies. Consequently, late initialized germinal centers have a compromised output due to higher antibody feedback from the germinal centers formed earlier. The results demonstrate potential effects of germinal center intercommunication and highlight the importance of understanding germinal center interactions for optimizing the antibody response, in particular, in the elderly and in the context of vaccination.
CitationFront Immunol. 2019 Sep 6;10:2116. doi: 10.3389/fimmu.2019.02116. eCollection 2019.
AffiliationBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.
JournalFrontiers in Immunology
The following license files are associated with this item:
- Stochastic discrete event simulation of germinal center reactions.
- Authors: Figge MT
- Issue date: 2005 May
- A mathematical model for germinal centre kinetics and affinity maturation.
- Authors: Iber D, Maini PK
- Issue date: 2002 Nov 21
- Dynamics of one-pass germinal center models: implications for affinity maturation.
- Authors: Oprea M, van Nimwegen E, Perelson AS
- Issue date: 2000 Jan
- Germinal centers: programmed for affinity maturation and antibody diversification.
- Authors: Bannard O, Cyster JG
- Issue date: 2017 Apr
- How to Simulate a Germinal Center.
- Authors: Robert PA, Rastogi A, Binder SC, Meyer-Hermann M
- Issue date: 2017