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dc.contributor.authorArulraj, Theinmozhi
dc.contributor.authorBinder, Sebastian C
dc.contributor.authorRobert, Philippe A
dc.contributor.authorMeyer-Hermann, Michael
dc.date.accessioned2019-10-17T10:56:26Z
dc.date.available2019-10-17T10:56:26Z
dc.date.issued2019-01-01
dc.identifier.citationFront Immunol. 2019 Sep 6;10:2116. doi: 10.3389/fimmu.2019.02116. eCollection 2019.en_US
dc.identifier.issn1664-3224
dc.identifier.pmid31555300
dc.identifier.doi10.3389/fimmu.2019.02116
dc.identifier.urihttp://hdl.handle.net/10033/621981
dc.description.abstractThe germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using an agent-based model of the germinal center reaction, we studied the impact of antibody feedback on kinetics and efficiency of a germinal center. Our simulations predict that high feedback of antibodies from germinal centers reduces the production of plasma cells and subsequently the efficiency of the germinal center reaction by promoting earlier termination. Affinity maturation is only weakly improved by increased antibody feedback and ultimately interrupted because of premature termination of the reaction. The model predicts that the asynchronous onset and changes in number of germinal centers could alter the efficiency of antibody response due to changes in feedback by soluble antibodies. Consequently, late initialized germinal centers have a compromised output due to higher antibody feedback from the germinal centers formed earlier. The results demonstrate potential effects of germinal center intercommunication and highlight the importance of understanding germinal center interactions for optimizing the antibody response, in particular, in the elderly and in the context of vaccination.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/ 765158en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectantibody productionen_US
dc.subjectcomputer simulationen_US
dc.subjectgerminal centeren_US
dc.subjectmathematical modelingen_US
dc.subjectvaccinationen_US
dc.titleSynchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses.en_US
dc.typeArticleen_US
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in Immunologyen_US
refterms.dateFOA2019-10-17T10:56:27Z
dc.source.journaltitleFrontiers in immunology


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