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dc.contributor.authorWiegand, Steffen B.
dc.contributor.authorBeggel, Bastian
dc.contributor.authorWranke, Anika
dc.contributor.authorAliabadi, Elmira
dc.contributor.authorJaroszewicz, Jerzy
dc.contributor.authorXu, Cheng Jian
dc.contributor.authorLi, Yang
dc.contributor.authorManns, Michael P.
dc.contributor.authorLengauer, Thomas
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorKraft, Anke R.M.
dc.contributor.authorFalk, Christine S.
dc.contributor.authorCornberg, Markus
dc.creatorWiegand, S.
dc.date.accessioned2019-10-18T14:22:12Z
dc.date.available2019-10-18T14:22:12Z
dc.date.issued2019-10-01
dc.identifier.citationSci Rep. 2019 Oct 1;9(1):14118. doi: 10.1038/s41598-019-50729-5.en_US
dc.identifier.pmid31575964
dc.identifier.doi10.1038/s41598-019-50729-5
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072848113&origin=inward
dc.identifier.urihttp://hdl.handle.net/10033/621986
dc.description.abstractChronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral treatment. Currently, host responses reflected by immune markers are not considered in this definition. We aimed to study soluble immune markers and their distribution in different phases of chronic HBV infection. In this cross-sectional retrospective study, we investigated a panel of 14 soluble immune markers (SIM) including CXCL10 in 333 patients with chronic HBV infection. In a small cohort of HBeAg positive patients we analyzed SIM before and after HBeAg seroconversion and compared seroconverters to patients with unknown outcome. Significant differences were documented in the levels of several SIM between the four phases of chronic HBV infection. The most pronounced difference among all investigated SIM was observed for CXCL10 concentrations with highest levels in patients with hepatitis. TGF-β and IL-17 revealed different levels between HBeAg negative patients. HBeAg positive patients with HBeAg seroconversion presented higher amounts of IL-12 before seroconversion compared to HBeAg positive patients with unknown follow up. SIM such as CXCL10 but also IL-12, TGF-β and IL-17 may be useful markers to further characterize the phase of chronic HBV infection.en_US
dc.language.isoenen_US
dc.publisherNature publishing groupen_US
dc.relation.ispartofScientific reports
dc.relation.ispartofseries1en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleSoluble immune markers in the different phases of chronic hepatitis B virus infectionen_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalScientific reportsen_US
dc.identifier.eid2-s2.0-85072848113
dc.identifier.scopusidSCOPUS_ID:85072848113
dc.relation.volume9
refterms.dateFOA2019-10-18T14:22:13Z


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