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dc.contributor.authorLabib, Rola M
dc.contributor.authorAyoub, Iriny M
dc.contributor.authorMichel, Haidy E
dc.contributor.authorMehanny, Mina
dc.contributor.authorKamil, Verena
dc.contributor.authorHany, Meryl
dc.contributor.authorMagdy, Mirette
dc.contributor.authorMoataz, Aya
dc.contributor.authorMaged, Boula
dc.contributor.authorMohamed, Ahmed
dc.date.accessioned2019-10-21T13:42:59Z
dc.date.available2019-10-21T13:42:59Z
dc.date.issued2019-01-01
dc.identifier.citationPLoS One. 2019 Sep 16;14(9):e0219561. doi: 10.1371/journal.pone.0219561. eCollection 2019.en_US
dc.identifier.issn1932-6203
dc.identifier.pmid31525200
dc.identifier.doi10.1371/journal.pone.0219561
dc.identifier.urihttp://hdl.handle.net/10033/621987
dc.description.abstractThe present study investigates the wound healing potential of three chitosan-based topical preparations loaded with either tea tree essential oil, rosemary essential oil or a mixture of both oils in vivo. Essential oils of M. alternifolia and R. officinalis were analyzed using GC/MS. Essential oil-loaded chitosan topical preparations were formulated. Wound healing potential was evaluated in vivo using an excision wound model in rats. GC/MS analysis of M. alternifolia and R. officinalis essential oils revealed richness in oxygenated monoterpenes, representing 51.06% and 69.61% of the total oil composition, respectively. Topical application of chitosan-based formulation loaded with a mixture of tea tree and rosemary oils resulted in a significant increase in wound contraction percentage compared to either group treated with individual essential oils and the untreated group. Histopathological examination revealed that topical application of tea tree and rosemary oil combination demonstrated complete re-epithelialization associated with activated hair follicles. The high percentage of oxygenated monoterpenes in both essential oils play an important role in the antioxidant and wound healing potential observed herein. Incorporation of tea tree and rosemary essential oils in chitosan-based preparations in appropriate combination could efficiently promote different stages of wound healing.en_US
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleAppraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalPLOS ONEen_US
refterms.dateFOA2019-10-21T13:43:00Z
dc.source.journaltitlePloS one


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