Show simple item record

dc.contributor.authorMeyerholz, M M
dc.contributor.authorRohmeier, L
dc.contributor.authorEickhoff, T
dc.contributor.authorHülsebusch, A
dc.contributor.authorJander, S
dc.contributor.authorLinden, M
dc.contributor.authorMacias, L
dc.contributor.authorKoy, M
dc.contributor.authorHeimes, A
dc.contributor.authorGorríz-Martín, L
dc.contributor.authorSegelke, D
dc.contributor.authorEngelmann, S
dc.contributor.authorSchmicke, M
dc.contributor.authorHoedemaker, M
dc.contributor.authorPetzl, W
dc.contributor.authorZerbe, H
dc.contributor.authorSchuberth, H-J
dc.contributor.authorKühn, Ch
dc.date.accessioned2019-10-22T09:19:14Z
dc.date.available2019-10-22T09:19:14Z
dc.date.issued2019-11-01
dc.identifier.citationJ Dairy Sci. 2019 Nov;102(11):9983-9994. doi: 10.3168/jds.2018-16171. Epub 2019 Sep 11.en_US
dc.identifier.issn1525-3198
dc.identifier.pmid31521359
dc.identifier.doi10.3168/jds.2018-16171
dc.identifier.urihttp://hdl.handle.net/10033/621989
dc.description.abstractThe susceptibility of animals to periparturient diseases has a great effect on the economic efficiency of dairy industries, on the frequency of antibiotic treatment, and on animal welfare. The use of selection for breeding cows with reduced susceptibility to diseases offers a sustainable tool to improve dairy cattle farming. Several studies have focused on the association of distinct bovine chromosome 18 genotypes or haplotypes with performance traits. The aim of this study was to test whether selection of Holstein Friesian heifers via SNP genotyping for alternative paternal chromosome 18 haplotypes associated with favorable (Q) or unfavorable (q) somatic cell scores influences postpartum reproductive and metabolic diseases. Thirty-six heifers (18 Q and 18 q) were monitored from 3 wk before calving until necropsy on d 39 (± 4 d) after calving. Health status and rectal temperature were measured daily, and body condition score and body weight were assessed once per week. Blood samples were drawn twice weekly, and levels of insulin, nonesterified fatty acids, insulin-like growth factor-I, growth hormone, and β-hydroxybutyrate were measured. Comparisons between the groups were performed using Fisher's exact test, chi-squared test, and the GLIMMIX procedure in SAS. Results showed that Q-heifers had reduced incidence of metritis compared with q-heifers and were less likely to develop fever. Serum concentrations of β-hydroxybutyrate were lower and insulin-like growth factor-I plasma concentrations were higher in Q- compared with q-heifers. However, the body condition score and withers height were comparable between haplotypes, but weight loss tended to be lower in Q-heifers compared with q-heifers. No differences between the groups were detected concerning retained fetal membranes, uterine involution, or onset of cyclicity. In conclusion, selection of chromosome 18 haplotypes associated with a reduced somatic cell score resulted in a decreased incidence of postpartum reproductive and metabolic diseases in this study. The presented data add to the existing knowledge aimed at avoiding negative consequences of genetic selection strategies in dairy cattle farming. The underlying causal mechanisms modulated by haplotypes in the targeted genomic region and immune competence necessitate further investigation.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBTA18en_US
dc.subjectinsulin-like growth factor-Ien_US
dc.subjectmetritisen_US
dc.subjectsomatic cell scoreen_US
dc.titleGenetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournal of Dairy Scienceen_US
refterms.dateFOA2019-10-22T09:19:15Z
dc.source.journaltitleJournal of dairy science


Files in this item

Thumbnail
Name:
Meyerholz et al.pdf
Size:
1.018Mb
Format:
PDF
Description:
Open Access article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International