Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsKleinert, Robin D V
Brown, Richard J P
MetadataShow full item record
AbstractYellow fever virus (YFV) represents a re-emerging zoonotic pathogen, transmitted by mosquito vectors to humans from primate reservoirs. Sporadic outbreaks of YFV occur in endemic tropical regions, causing a viral hemorrhagic fever (VHF) associated with high mortality rates. Despite a highly effective vaccine, no antiviral treatments currently exist. Therefore, YFV represents a neglected tropical disease and is chronically understudied, with many aspects of YFV biology incompletely defined including host range, host-virus interactions and correlates of host immunity and pathogenicity. In this article, we review the current state of YFV research, focusing on the viral lifecycle, host responses to infection, species tropism and the success and associated limitations of the YFV-17D vaccine. In addition, we highlight the current lack of available treatments and use publicly available sequence and structural data to assess global patterns of YFV sequence diversity and identify potential drug targets. Finally, we discuss how technological advances, including real-time epidemiological monitoring of outbreaks using next-generation sequencing and CRISPR/Cas9 modification of vector species, could be utilized in future battles against this re-emerging pathogen which continues to cause devastating disease
CitationViruses. 2019 Oct 17;11(10). pii: v11100960. doi: 10.3390/v11100960.
AffiliationTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo.
- Authors: Douam F, Soto Albrecht YE, Hrebikova G, Sadimin E, Davidson C, Kotenko SV, Ploss A
- Issue date: 2017 Aug 15
- Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease.
- Authors: Silva NIO, Sacchetto L, de Rezende IM, Trindade GS, LaBeaud AD, de Thoisy B, Drumond BP
- Issue date: 2020 Jan 23
- Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe.
- Authors: Douam F, Ploss A
- Issue date: 2018 Nov
- Neighbor danger: Yellow fever virus epizootics in urban and urban-rural transition areas of Minas Gerais state, during 2017-2018 yellow fever outbreaks in Brazil.
- Authors: Sacchetto L, Silva NIO, Rezende IM, Arruda MS, Costa TA, de Mello ÉM, Oliveira GFG, Alves PA, de Mendonça VE, Stumpp RGAV, Prado AIA, Paglia AP, Perini FA, Lacerda Nogueira M, Kroon EG, de Thoisy B, Trindade GS, Drumond BP
- Issue date: 2020 Oct
- A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies.
- Authors: Mishra N, Boudewijns R, Schmid MA, Marques RE, Sharma S, Neyts J, Dallmeier K
- Issue date: 2020 Apr 7