Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus.
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Authors
Kleinert, Robin D VMontoya-Diaz, Eduardo
Khera, Tanvi
Welsch, Kathrin
Tegtmeyer, Birthe
Hoehl, Sebastian
Ciesek, Sandra
Brown, Richard J P
Issue Date
2019-10-17
Metadata
Show full item recordAbstract
Yellow fever virus (YFV) represents a re-emerging zoonotic pathogen, transmitted by mosquito vectors to humans from primate reservoirs. Sporadic outbreaks of YFV occur in endemic tropical regions, causing a viral hemorrhagic fever (VHF) associated with high mortality rates. Despite a highly effective vaccine, no antiviral treatments currently exist. Therefore, YFV represents a neglected tropical disease and is chronically understudied, with many aspects of YFV biology incompletely defined including host range, host-virus interactions and correlates of host immunity and pathogenicity. In this article, we review the current state of YFV research, focusing on the viral lifecycle, host responses to infection, species tropism and the success and associated limitations of the YFV-17D vaccine. In addition, we highlight the current lack of available treatments and use publicly available sequence and structural data to assess global patterns of YFV sequence diversity and identify potential drug targets. Finally, we discuss how technological advances, including real-time epidemiological monitoring of outbreaks using next-generation sequencing and CRISPR/Cas9 modification of vector species, could be utilized in future battles against this re-emerging pathogen which continues to cause devastating diseaseCitation
Viruses. 2019 Oct 17;11(10). pii: v11100960. doi: 10.3390/v11100960.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.Publisher
MPDIJournal
VirusesPubMed ID
31627415Type
ArticleLanguage
enISSN
1999-4915ae974a485f413a2113503eed53cd6c53
10.3390/v11100960
Scopus Count
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