Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractPrecisely controlling the excitatory and inhibitory balance is crucial for the stability and information-processing ability of neuronal networks. However, the molecular mechanisms maintaining this balance during ongoing sensory experiences are largely unclear. We show that Nogo-A signaling reciprocally regulates excitatory and inhibitory transmission. Loss of function for Nogo-A signaling through S1PR2 rapidly increases GABAAR diffusion, thereby decreasing their number at synaptic sites and the amplitude of GABAergic mIPSCs at CA3 hippocampal neurons. This increase in GABAAR diffusion rate is correlated with an increase in Ca2+ influx and requires the calcineurin-mediated dephosphorylation of the γ2 subunit at serine 327. These results suggest that Nogo-A signaling rapidly strengthens inhibitory GABAergic transmission by restricting the diffusion dynamics of GABAARs. Together with the observation that Nogo-A signaling regulates excitatory transmission in an opposite manner, these results suggest a crucial role for Nogo-A signaling in modulating the excitation and inhibition balance to restrict synaptic plasticity.
CitationCell Rep. 2019 Oct 15;29(3):671-684.e6. doi: 10.1016/j.celrep.2019.09.015.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.
- Authors: Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC
- Issue date: 2018 Jan
- Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics.
- Authors: Kellner Y, Fricke S, Kramer S, Iobbi C, Wierenga CJ, Schwab ME, Korte M, Zagrebelsky M
- Issue date: 2016 Jun
- Nogo-A regulates spatial learning as well as memory formation and modulates structural plasticity in the adult mouse hippocampus.
- Authors: Zagrebelsky M, Lonnemann N, Fricke S, Kellner Y, Preuß E, Michaelsen-Preusse K, Korte M
- Issue date: 2017 Feb
- Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics.
- Authors: Bannai H, Lévi S, Schweizer C, Inoue T, Launey T, Racine V, Sibarita JB, Mikoshiba K, Triller A
- Issue date: 2009 Jun 11
- The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.
- Authors: Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME
- Issue date: 2014 Jan