Sparticolins A-G, Biologically Active Oxidized Spirodioxynaphthalene Derivatives from the Ascomycete Sparticola junci.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Macabeo, Allan Patrick G
Hyde, Kevin D
MetadataShow full item record
AbstractTo explore the chemical diversity of metabolites from new species of Dothideomycetes, the ex-type strain of Sparticola junci was investigated. Seven highly oxygenated and functionalized spirodioxynaphthalene natural products incorporating carboxyalkylidene-cyclopentanoid (1-4), carboxyl-functionalized oxabicyclo[3.3.0]octane (5-6), and annelated 2-cyclopentenone/δ-lactone (7) units, sparticolins A-G, were isolated from submerged cultures of the fungus. Their chemical structures including their relative (and absolute) configurations were established through spectroscopic and X-ray crystallographic analyses. Sparticolin B (2) exhibited inhibitory activity against the Gram-positive bacteria Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus, while sparticolin G (7) showed antifungal activities against Schizosaccharomyces pombe and Mucor hiemalis. All other sparticolins were only weakly active against S. aureus and also showed weak activities against the nematode Caenorhabditis elegans. Compounds 2 and 7 also showed moderate cytotoxic activities against seven mammalian cell lines.
CitationJ Nat Prod. 2019 Oct 25;82(10):2878-2885. doi: 10.1021/acs.jnatprod.9b00604. Epub 2019 Oct 10.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
PublisherAmerican Society of Chemistry
JournalJournal of Natural Products
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis.
- Authors: Lei H, Lin X, Han L, Ma J, Ma Q, Zhong J, Liu Y, Sun T, Wang J, Huang X
- Issue date: 2017 Mar 13
- N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluation.
- Authors: Asadipour A, Moshafi MH, Khosravani L, Moghimi S, Amou E, Firoozpour L, Ilbeigi G, Beiki K, Soleimani E, Foroumadi A
- Issue date: 2018 Dec
- Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum.
- Authors: Basnet BB, Chen B, Suleimen YM, Ma K, Guo S, Bao L, Huang Y, Liu H
- Issue date: 2019 Sep
- New Antibacterial Phenone Derivatives Asperphenone A-C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1.
- Authors: Guo ZK, Zhou YQ, Han H, Wang W, Xiang L, Deng XZ, Ge HM, Jiao RH
- Issue date: 2018 Jan 30
- Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities.
- Authors: Köpcke B, Johansson M, Sterner O, Anke H
- Issue date: 2002 Jan