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dc.contributor.authorPhukhamsakda, Chayanard
dc.contributor.authorMacabeo, Allan Patrick G
dc.contributor.authorHuch, Volker
dc.contributor.authorCheng, Tian
dc.contributor.authorHyde, Kevin D
dc.contributor.authorStadler, Marc
dc.date.accessioned2019-11-13T09:20:43Z
dc.date.available2019-11-13T09:20:43Z
dc.date.issued2019-10-25
dc.identifier.citationJ Nat Prod. 2019 Oct 25;82(10):2878-2885. doi: 10.1021/acs.jnatprod.9b00604. Epub 2019 Oct 10.en_US
dc.identifier.issn1520-6025
dc.identifier.pmid31599583
dc.identifier.doi10.1021/acs.jnatprod.9b00604
dc.identifier.urihttp://hdl.handle.net/10033/622013
dc.description.abstractTo explore the chemical diversity of metabolites from new species of Dothideomycetes, the ex-type strain of Sparticola junci was investigated. Seven highly oxygenated and functionalized spirodioxynaphthalene natural products incorporating carboxyalkylidene-cyclopentanoid (1-4), carboxyl-functionalized oxabicyclo[3.3.0]octane (5-6), and annelated 2-cyclopentenone/δ-lactone (7) units, sparticolins A-G, were isolated from submerged cultures of the fungus. Their chemical structures including their relative (and absolute) configurations were established through spectroscopic and X-ray crystallographic analyses. Sparticolin B (2) exhibited inhibitory activity against the Gram-positive bacteria Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus, while sparticolin G (7) showed antifungal activities against Schizosaccharomyces pombe and Mucor hiemalis. All other sparticolins were only weakly active against S. aureus and also showed weak activities against the nematode Caenorhabditis elegans. Compounds 2 and 7 also showed moderate cytotoxic activities against seven mammalian cell lines.en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Chemistryen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleSparticolins A-G, Biologically Active Oxidized Spirodioxynaphthalene Derivatives from the Ascomycete Sparticola junci.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournal of Natural Productsen_US
dc.source.journaltitleJournal of natural products


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