Sparticolins A-G, Biologically Active Oxidized Spirodioxynaphthalene Derivatives from the Ascomycete Sparticola junci.
dc.contributor.author | Phukhamsakda, Chayanard | |
dc.contributor.author | Macabeo, Allan Patrick G | |
dc.contributor.author | Huch, Volker | |
dc.contributor.author | Cheng, Tian | |
dc.contributor.author | Hyde, Kevin D | |
dc.contributor.author | Stadler, Marc | |
dc.date.accessioned | 2019-11-13T09:20:43Z | |
dc.date.available | 2019-11-13T09:20:43Z | |
dc.date.issued | 2019-10-25 | |
dc.identifier.citation | J Nat Prod. 2019 Oct 25;82(10):2878-2885. doi: 10.1021/acs.jnatprod.9b00604. Epub 2019 Oct 10. | en_US |
dc.identifier.issn | 1520-6025 | |
dc.identifier.pmid | 31599583 | |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00604 | |
dc.identifier.uri | http://hdl.handle.net/10033/622013 | |
dc.description.abstract | To explore the chemical diversity of metabolites from new species of Dothideomycetes, the ex-type strain of Sparticola junci was investigated. Seven highly oxygenated and functionalized spirodioxynaphthalene natural products incorporating carboxyalkylidene-cyclopentanoid (1-4), carboxyl-functionalized oxabicyclo[3.3.0]octane (5-6), and annelated 2-cyclopentenone/δ-lactone (7) units, sparticolins A-G, were isolated from submerged cultures of the fungus. Their chemical structures including their relative (and absolute) configurations were established through spectroscopic and X-ray crystallographic analyses. Sparticolin B (2) exhibited inhibitory activity against the Gram-positive bacteria Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus, while sparticolin G (7) showed antifungal activities against Schizosaccharomyces pombe and Mucor hiemalis. All other sparticolins were only weakly active against S. aureus and also showed weak activities against the nematode Caenorhabditis elegans. Compounds 2 and 7 also showed moderate cytotoxic activities against seven mammalian cell lines. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Society of Chemistry | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | Sparticolins A-G, Biologically Active Oxidized Spirodioxynaphthalene Derivatives from the Ascomycete Sparticola junci. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Journal of Natural Products | en_US |
dc.source.journaltitle | Journal of natural products |