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dc.contributor.authorMeyer-Hermann, Michael
dc.date.accessioned2019-11-19T14:59:46Z
dc.date.available2019-11-19T14:59:46Z
dc.date.issued2019-10-29
dc.identifier.citationCell Rep. 2019 Oct 29;29(5):1066-1073.e5. doi: 10.1016/j.celrep.2019.09.058.en_US
dc.identifier.issn2211-1247
dc.identifier.pmid31665624
dc.identifier.doi10.1016/j.celrep.2019.09.058
dc.identifier.urihttp://hdl.handle.net/10033/622019
dc.description.abstractBroadly neutralizing antibodies are crucial for the control of many life-threatening viral infections like HIV, influenza, or hepatitis. Their induction is a prime goal in vaccine research. Using computer simulations, we identify strategies to promote the generation of broadly neutralizing antibodies in natural germinal center (GC) reactions. The simulations predict a feedback loop based on antibodies and memory B cells from previous GC reactions that promotes GCs to focus on new epitopes. Memory-derived or injected antibodies specific for immunodominant epitopes control epitope availability, suppress the participation of memory B cells in the GC reaction, and allow for the evolution of other B cells to affinity mature for hidden or rare epitopes. This defines a natural selection mechanism for GC B cells to concentrate on new epitopes rather than refine affinity to already-covered epitopes. This principle can be used for the design and testing of future therapies and vaccination protocols.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHIVen_US
dc.subjectbroadly neutralizing antibodiesen_US
dc.subjectgerminal centeren_US
dc.subjecthepatitisen_US
dc.subjectinfluenzaen_US
dc.subjectmathematical modelingen_US
dc.subjectmemory B cellsen_US
dc.subjectoriginal antigenic sinen_US
dc.subjectsimulationen_US
dc.subjecttargeting hidden epitopesen_US
dc.titleInjection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies.en_US
dc.typeArticleen_US
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalCell Reportsen_US
refterms.dateFOA2019-11-19T14:59:47Z
dc.source.journaltitleCell reports


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International