The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.

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Authors
Formicola, Beatrice
Dal Magro, Roberta
Montefusco-Pereira, Carlos V
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A
Danani, Andrea
Bourdoulous, Sandrine
Issue Date
2019-11-11

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Abstract
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
Citation
J Nanobiotechnology. 2019 Nov 11;17(1):115. doi: 10.1186/s12951-019-0546-3.
Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
Publisher
BMC
Journal
Journal of nanobiotechnology
URI
http://hdl.handle.net/10033/622022
DOI
10.1186/s12951-019-0546-3
PubMed ID
31711496
Type
Article
Language
en
ISSN
1477-3155
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