The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.
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Authors
Formicola, BeatriceDal Magro, Roberta
Montefusco-Pereira, Carlos V
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A
Danani, Andrea
Bourdoulous, Sandrine
Re, Francesca
Issue Date
2019-11-11
Metadata
Show full item recordAbstract
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.Citation
J Nanobiotechnology. 2019 Nov 11;17(1):115. doi: 10.1186/s12951-019-0546-3.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
BMCJournal
Journal of nanobiotechnologyPubMed ID
31711496Type
ArticleLanguage
enISSN
1477-3155ae974a485f413a2113503eed53cd6c53
10.1186/s12951-019-0546-3
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
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