The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.

Formicola, Beatrice; Dal Magro, Roberta; Montefusco-Pereira, Carlos V; Lehr, Claus-Michael; Koch, Marcus; Russo, Laura; Grasso, Gianvito; Deriu, Marco A; Danani, Andrea; Bourdoulous, Sandrine; Re, Francesca

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Authors

Formicola, Beatrice
Dal Magro, Roberta
Montefusco-Pereira, Carlos V
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A
Danani, Andrea
Bourdoulous, Sandrine

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Issue Date

2019-11-11

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Abstract

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

Citation

J Nanobiotechnology. 2019 Nov 11;17(1):115. doi: 10.1186/s12951-019-0546-3.

Affiliation

HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

Type

Article

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ISSN

1477-3155

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publications of the department drug delivery ([HIPS] DDEL)

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