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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.

dc.contributor.authorFormicola, Beatrice
dc.contributor.authorDal Magro, Roberta
dc.contributor.authorMontefusco-Pereira, Carlos V
dc.contributor.authorLehr, Claus-Michael
dc.contributor.authorKoch, Marcus
dc.contributor.authorRusso, Laura
dc.contributor.authorGrasso, Gianvito
dc.contributor.authorDeriu, Marco A
dc.contributor.authorDanani, Andrea
dc.contributor.authorBourdoulous, Sandrine
dc.contributor.authorRe, Francesca
dc.date.accessioned2019-11-20T15:36:02Z
dc.date.available2019-11-20T15:36:02Z
dc.date.issued2019-11-11
dc.identifier.citationJ Nanobiotechnology. 2019 Nov 11;17(1):115. doi: 10.1186/s12951-019-0546-3.en_US
dc.identifier.issn1477-3155
dc.identifier.pmid31711496
dc.identifier.doi10.1186/s12951-019-0546-3
dc.identifier.urihttp://hdl.handle.net/10033/622022
dc.description.abstractWe designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBlood–brain barrieren_US
dc.subjectBrainen_US
dc.subjectChlorotoxinen_US
dc.subjectDoxorubicinen_US
dc.subjectDrug deliveryen_US
dc.subjectGlioblastomaen_US
dc.subjectLiposomesen_US
dc.subjectNanoparticlesen_US
dc.titleThe synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalJournal of nanobiotechnologyen_US
refterms.dateFOA2019-11-20T15:36:02Z
dc.source.journaltitleJournal of nanobiotechnology


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International