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dc.contributor.authorQi, Cancan
dc.contributor.authorXu, Cheng-Jian
dc.contributor.authorKoppelman, Gerard H
dc.date.accessioned2019-11-22T12:47:16Z
dc.date.available2019-11-22T12:47:16Z
dc.date.issued2019-11-10
dc.identifier.issn1744-8409
dc.identifier.pmid31674254
dc.identifier.doi10.1080/1744666X.2020.1686977
dc.identifier.urihttp://hdl.handle.net/10033/622025
dc.descriptionReviewen_US
dc.description.abstractIntroduction: The development of childhood asthma is caused by a combination of genetic factors and environmental exposures. Epigenetics describes mechanisms of (heritable) regulation of gene expression that occur without changes in DNA sequence. Epigenetics is strongly related to aging, is cell-type specific, and includes DNA methylation, noncoding RNAs, and histone modifications.Areas covered: This review summarizes recent epigenetic studies of childhood asthma in humans, which mostly involve studies of DNA methylation published in the recent five years. Environmental exposures, in particular cigarette smoking, have significant impact on epigenetic changes, but few of these epigenetic signals are also associated with asthma. Several asthma-associated genetic variants relate to DNA methylation. Epigenetic signals can be better understood by studying their correlation with gene expression, which revealed higher presence and activation of blood eosinophils in asthma. Strong associations of nasal methylation signatures and atopic asthma were identified, which were replicable across different populations.Expert commentary: Epigenetic markers have been strongly associated with asthma, and might serve as biomarker of asthma. The causal and longitudinal relationships between epigenetics and disease, and between environmental exposures and epigenetic changes need to be further investigated. Efforts should be made to understand cell-type-specific epigenetic mechanisms in asthma.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAsthmaen_US
dc.subjectDNA methylationen_US
dc.subjectcell typesen_US
dc.subjectenvironmental exposuresen_US
dc.subjectepigeneticsen_US
dc.titleThe role of epigenetics in the development of childhood asthma.en_US
dc.typeOtheren_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
refterms.dateFOA2019-11-22T12:47:17Z
dc.source.journaltitleExpert review of clinical immunology


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Attribution-NonCommercial-ShareAlike 4.0 International
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