The role of Ames dwarfism and calorie restriction on gut microbiota.
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Authors
Wiesenborn, Denise SGálvez, Eric J C
Spinel, Lina
Victoria, Berta
Allen, Brittany
Schneider, Augusto
Gesing, Adam
Al-Regaiey, Khalid A
Strowig, Till

Schäfer, Karl-Herbert
Masternak, Michal M
Issue Date
2019-10-30
Metadata
Show full item recordAbstract
The gut microbiome (GM) represents a large and very complex ecosystem of different microorganisms. There is an extensive interest in the potential role of the GM in different diseases including cancer, diabetes, cardiovascular diseases, and aging. The GM changes over the lifespan and is strongly associated with various age-related diseases. Ames dwarf (df/df) mice are characterized by an extended life- and healthspan, and although these mice are protected from many age-related diseases, their microbiome has not been studied. To determine the role of microbiota on longevity animal models, we investigated the changes in the GM of df/df and Normal control (N) mice, by comparing parents before mating and littermate mice at three distinct time points during early life. Furthermore, we studied the effects of a 6-month calorie restriction (CR), the most powerful intervention extending the lifespan. Our data revealed significant changes of the GM composition during early life development, and we detected differences in the abundance of some bacteria between df/df and N mice, already in early life. Overall, the variability of the microbiota by genotype, time-point and breeding pair showed significant differences. In addition, CR caused significant changes in microbiome according to gastrointestinal (GI) location (distal colon, ileum and cecum), genotype and diet. However, the overall impact of the genotype was more prominent than that of the CR. In conclusion, our findings suggest that the gut microbiota plays an important role during post-natal development in long-living df/df mice and CR dietary regimen can significantly modulate the GM.Citation
J Gerontol A Biol Sci Med Sci. 2019 Oct 30. pii: 5609456. doi: 10.1093/gerona/glz236.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
Oxford AcademicJournal
Journals of Gerontology Series APubMed ID
31665244Type
ArticleLanguage
enISSN
1758-535Xae974a485f413a2113503eed53cd6c53
10.1093/gerona/glz236
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
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